高清福利片

You may have heard reports in recent days of a 鈥溾�� spreading in Japan, referring to an illness that can occur with streptococcal toxic shock syndrome (STSS).

Media reports indicate the country has seen聽聽of STSS in the first six months of 2024, more than the total for all of 2023. However, these cases have not yet been published in peer-reviewed journals, so reports may not be entirely accurate.

STSS is caused by聽Streptococcus pyogenes聽bacteria, or 鈥淪trep A鈥�. These bacteria are quite common, but certain strains can cause more serious illness 鈥� called invasive group A streptococcal disease.

Since 2022, many countries, including聽, the聽, and countries聽, have noted a rise in severe invasive group A streptococcal disease. This surge is part of an overall increase in聽.

So what is STSS, why is it surging now, and is it cause for concern?

At any time,聽聽will be 鈥渃olonised鈥� with Strep A, meaning the bacteria is living harmlessly in their throat or on their skin.

Strep A also causes sore throats (鈥渟trep throat鈥�) and skin infections. Sometimes, for reasons that still aren鈥檛 entirely clear, Strep A causes invasive infections like pneumonia, nasty 鈥渇lesh-eating鈥� skin infections, and STSS. In these ways, Strep A is an important cause of sepsis, a term which broadly refers to a life-threatening infection.

STSS is the most severe Strep A disease, though fortunately it鈥檚 really rare. It mostly affects young children and聽聽but cases do occur at all ages. Pregnant people may also be at聽, including soon after delivery.

滨苍听, the bacteria produces a toxin that can result in an overwhelming immune response in some people.

The illness can progress to become life-threatening in a matter of hours and has a high mortality rate 鈥撀犅爋f people who develop STSS will die.

However, the early signs and symptoms of STSS can overlap with common viral illnesses, particularly in children, making it hard to diagnose.

Symptoms are vague in early invasive group A streptococcal infections 鈥� things like fever, rash and nausea. But it鈥檚 important to look out for聽, which suggests something more serious might be going on.

Signs of more severe invasive group A streptococcal disease, including STSS, are similar to those seen in other bacterial causes of sepsis (such as meningococcal disease). These include lethargy (drowsiness), fast breathing, a rapidly changing rash, aching muscles and confusion.

STSS sometimes co-occurs with a condition called necrotizing fasciitis, also caused by Strep A, which is the 鈥渇lesh-eating鈥� presentation of the infection. This is when the skin cells die in response to the toxins produced by the bacteria.

Parents of young children should trust their gut. If you鈥檙e worried your child is sicker than they usually would be with a common bug, and particularly if they have cold limbs, a red rash (like sunburn), or are less responsive, seek medical attention quickly at your nearest emergency department.

Studies suggest certain聽聽of Strep A might be one part of the current STSS surge.

Also, in 2020鈥�21, at the height of the COVID pandemic, when there was less close contact between people, there was likewise less exposure to Strep A (and other bacteria and viruses). For younger children especially, that meant they didn鈥檛聽聽against bad Strep A infections that comes from repeated exposure.

With more human contact from 2022 onward, there has been more transmission of Strep A, with children more vulnerable to contracting more severe disease, including STSS.

This is not unique to Japan. Although rare, we鈥檝e seen many cases of STSS聽聽and elsewhere.

Strep A can be killed by penicillin, one of the oldest and most widely available antibiotics. When STSS is diagnosed early, antibiotics usually prevent most serious complications.

Other medicines, like immunoglobulin, might be required to put the brakes on an out-of-control immune response, and patients often need support in an intensive care unit.

There鈥檚 no vaccine to prevent STSS and other Strep A infections (unlike other bacteria like meningococcus and pneumococcus, which are in the聽).

Researchers in Australia and around the world are working hard to try to find a聽听颈苍蹿别肠迟颈辞苍蝉.

Serious Strep A infections like STSS often follow viral infections, especially聽听补苍诲听, so staying up to date with vaccines in the聽聽(which includes chickenpox), and ensuring you receive the seasonal influenza vaccine,聽.

Strep A can be spread via large respiratory droplets or direct contact with infected people or carriers. Simple聽聽(like hand washing and covering your cough) reduce the amount of Strep A circulating in the community.

STSS is a rare but serious complication of Strep A infections, which can occur in humans anywhere. So, unless you鈥檙e trekking alone to the South Pole, you鈥檙e at a very similar (and very low) risk of contracting a serious infection.

Make sure you鈥檙e up to date with immunisations including the seasonal flu vaccine. Always practice good hand hygiene, and remember the signs of severe bacterial infections that require urgent medical attention.

The article was originally published in The Conversation as 聽written by Dr Phoebe Williams from the Sydney Infectious Diseases Institute, University of Sydney, Joshua Osowicki and Yara-Natalie Abo from Murdoch Children's Research Institute.聽

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