高清福利片

The researchers have called for more sophisticated diagnostic criteria and clinical record keeping to address their findings.

The study led by Ms Amira Skeggs, a clinical researcher in the School of Psychology, has been published in the . It focuses on one of three types of the disease known as behavioural variant frontotemporal dementia (bvFTD). In February, American actor Bruce Willis announced he had been diagnosed with frontotemporal dementia.

鈥淔rontotemporal dementia refers to a set of younger-onset dementia syndromes, which are typically diagnosed before the age of 65,鈥� Ms Skeggs said.

鈥淥ur findings suggest that current diagnostic methods might be less accurate at identifying symptoms in Australians from culturally diverse backgrounds.

鈥淲hen it comes to neurodegenerative syndromes like bvFTD, culturally diverse people can have a later onset of the disease compared to monolingual Australians because they have other factors which could increase their resilience or cognitive reserve.鈥�

Cognitive reserve is a kind of fortification that helps the brain weather progression of neurodegeneration before symptoms of mental decline emerge. This reserve is built up over an active lifetime and is influenced by a range of factors.

鈥淭here is a tendency for culturally diverse patients, particularly those who come to Australia, to have higher levels of cognitive reserve,鈥� Ms Skeggs said.

鈥淢ultilingualism, education, working in a complex profession for a long time, all of these factors add up and make you more resilient to cognitive decline 鈥� up to a point.

鈥淭he downside of this cognitive reserve is that it may cause diagnosis to be delayed or mistaken. At the point where the disease becomes visible to others, the patient鈥檚 cognition may decline steeply because they have had a sustained period of brain atrophy without it being addressed.鈥�

BvFTD is a progressive neurodegenerative disease that affects brain areas responsible for behaviour, personality, language and emotions. Degeneration of nerve cells in the brain leads to the loss of function in these areas, typically starting gradually and worsening over time.

In the study, researchers compared clinical symptoms of people with bvFTD based on culture and language for the first time. The 107 participants were separated into three groups: Australians who speak only English and two groups of culturally diverse people, one that spoke English as their first language and another that spoke a different tongue in the beginning.

鈥淐omparisons revealed that the group who spoke a non-English first language performed worse than the other groups on verbal tests but better on non-verbal tests,鈥� Ms Skeggs said.

鈥淭he poor verbal performance in the non-English speaking group is probably influenced by cultural biases within current clinical tests, so the reason they are showing decline may not actually be because they are declining.鈥�

Ms Skeggs said an interesting finding emerged where bilingual patients lost their second language.

鈥淲e had one Vietnamese patient who spoke English perfectly before disease onset, but by the time the disease had progressed, he had completely lost his English ability and could only communicate in Vietnamese, even though he had been speaking English perfectly for over 50 years,鈥� she said.

A major healthcare shortfall that needs to be updated for people with bvFTD, Ms Skeggs said, is the skewed diagnostic criteria, which has almost been built entirely on Western profiles. In Australia 29 percent of the population is born overseas.

鈥淎t the moment we probably don鈥檛 have an accurate and valid way of diagnosing symptoms or disease in culturally and linguistically diverse people,鈥� Ms Skeggs said.

鈥淐urrently, all the diagnostic criteria are based off Western samples, which means that it can be difficult to diagnose the diseases in non-Western people because they may not have the same symptoms.

鈥淭here is also some evidence that non-English-speaking patients are diagnosed at a later age, potentially due to a delay in clinical diagnosis or cognitive reserve slowing the disease onset.鈥�

The researchers said clinics should be collecting information about a patient鈥檚 cultural background, bilingualism and education, and offer alternatives during diagnosis such as a translator or image-based testing.

The study was conducted at聽, Australia鈥檚 largest specialist clinic for frontotemporal dementia.

DOI:

Declaration: This study was supported by ForeFront, a large collaborative research group dedicated to the study of neurodegenerative diseases and funded by the National Health and Medical Research Council of Australia Program Grant, Dementia Research Team Grant, and the ARC Centre of Excellence in Cognition and its Disorders.聽