高清福利片

Jawbone reconstruction 鈥� or orthognathic surgery 鈥� is a complicated medical procedure whereby a person's听jaw听is treated for significant trauma, such as from a car crash or gunshot wound, or diseases like oral cancer.

Jaw听reconstruction surgery involves replacing damaged or diseased bone tissue with an implant, typically a titanium plate or prosthesis, with patient recovery taking as long as twelve weeks. Complications like implant failure and infections are common, potentially requiring repeat surgery which can place significant burden on a patient.听

In recent years, biomedical engineers have developed a new generation of medical implants designed to not only substitute bone, but to help regenerate tissue back to its original state using 3D-printed tissue scaffold-fixation systems.

These devices enhance the innate healing potential of human tissue, using a scaffold as a temporary support structure for the surrounding cells to attach to and grow. Eventually, the scaffold is expected to dissolve into the blood stream, leaving new tissue in its place.

Ben Ferguson, a PhD student in the University of Sydney鈥檚 School of Aerospace, Mechanical and Mechatronic Engineering, is developing a surgical planning tool to assist surgeons in planning complex听jawbone reconstruction procedures using these new generation devices.听

Using advanced computational technology and decision-making algorithms, the tool works by generating a 鈥榙igital twin鈥� of the patient using CT scan data. It then rapidly simulates different designs of the implant before 3-D printing the final, optimal design,听allowing surgeons to perform a digital 鈥榬ehearsal鈥� prior to听theatre.听

鈥淣owadays, it would be unthinkable to construct a building without running an engineering simulation on it beforehand. This is the industry standard in civil engineering 鈥撎齮he same expectation should be applied to surgery on a human being,鈥� said Mr Ferguson, who is due to submit his PhD in September.

鈥淭he听jaw听is a complex area 鈥� required to talk, eat, chew and perform tasks that require both finesse and strength. Because of its complexity, we want to give orthognathic surgeons the best tools so they are set up for success 鈥� hopefully reducing repeat surgeries and improving patient outcomes.

鈥淎 bone implant design may work in one patient, but it may fail in another. If it was you 鈥� you would probably want a team of surgeons and biomedical engineers to run a simulation and assessment of the medical device in your body before it is actually implanted.鈥�

The surgical planning tool combines computer-aided design (CAD) tools with high-fidelity computer-aided engineering models and optimisation algorithms that can accurately simulate the medical device while under physiological load.听

鈥淚n addition to pre-surgical planning, this simulation data can also assist the surgeon in optimising the medical device's design, helping them resolve issues that inevitably arise when designing a device that must meet multiple design and medical objectives," said Professor听Qing Li,听Mr Ferguson鈥檚 supervisor.

鈥淚t is a careful balancing act. For example, an implant may need to mechanically stimulate the surrounding tissue to enhance healing, but mechanical stimulation may then increase the risk of implant failure. Our algorithms and data-driven approach help surgeons develop an optimal design without having to rely solely on intuition.鈥�

The researchers have recently partnered with Professor Jonathan听Clark听AM, Chair of Head and Neck Cancer Reconstructive Surgery at Chris O鈥橞rien Lifehouse to help translate the new technology into a clinical reality.

鈥淎ustralia has been a leader in听jaw听reconstruction since Dr Ian Taylor鈥檚 1974 breakthrough mandibular reconstruction. Since then,听jaw听reconstruction has evolved substantially: digital tools have been incorporated into pre-surgery planning, allowing surgeons to create more precise devices, with better aesthetic and functional outcomes for patients," said Professor Clark.听

鈥淲hat鈥檚 really exciting about this tool and data is that they provide the opportunity to evolve the technology beyond form, to also include biomechanical modeling, which can help predict the bone tissue鈥檚 response to physiological loads.

"This kind of analysis 鈥� termed CT-based finite element modelling 鈥撎齱ill be of great importance as we move away from using patient鈥檚 own bone听for reconstruction and start to incorporate customised scaffolds in the future.鈥�

DISCLOSURE

Mr Ferguson鈥檚 most recent paper was published in the听.听