Few doctors prescribe medical cannabis for chemo-induced nausea
鈥淎lthough medicinal cannabis can now be prescribed for chemotherapy-induced nausea and vomiting (CINV), high quality clinical trial evidence is required to determine its efficacy and safety,鈥� says the University of Sydney鈥檚 Dr Antony Mersiades, a co-author of the聽.
Recent legislation allows the prescription of medicinal cannabis by medical practitioners in Australia for the prevention and management of chemotherapy-induced nausea and vomiting.
Limited evidence and support for use of medicinal cannabis for chemo-indiced nausea
However, the most recent evidence-based guidelines for the prevention and management of CINV authored by leading global and Australian bodies provide limited support for use of medicinal cannabis.
As of July 2018, only 34 Australian doctors have taken up the offer to become registered prescribers of medicinal cannabis.
Medicinal cannabis can be prescribed for chemotherapy-induced nausea and vomiting (but) high quality clinical trial evidence is required to determine its efficacy and safety.
Dr Antony Mersiades, who is a Clinical Trials Fellow at the University of Sydney鈥檚 said the current situation illustrates 鈥渢he challenges of managing community demand for access to such products, and highlight the importance of conducting appropriately designed clinical trials鈥�.
Previous trials of cannabinoid products containing tetrahydrocannabidiol (THC), cannabidiol (CBD) or synthetic derivatives have been compromised by small sample sizes and outdated control arms, Mersiades and colleagues wrote.
One in particular was reported to show 鈥渁 promising efficacy signal and tolerable psychological adverse event profile鈥� despite the fact that one of the seven patients who received the active drug withdrew due to 鈥渢ransient psychotic symptoms鈥�, say the MJA authors.
鈥淭he Therapeutics Goods Administration guidance documents conclude that use of medicinal cannabis for CINV is experimental, and should only be considered for the management of intractable symptoms where standard therapies are ineffective,鈥� they wrote.
A clinical trial is currently underway in New South Wales to determine the efficacy, safety and cost-effectiveness of using medicinal cannabis to prevent chemotherapy-induced nausea and vomiting.
is being conducted by the University of Sydney, the Chris O鈥橞rien Lifehouse and other leading NSW cancer centres, and is funded by NSW Health. The trial has recruited over 60 of 80 planned participants for its phase 2 trial, with expansion to a 250-participant phase 3 trial planned if phase 2 results are encouraging.
鈥淭he results of such clinical trials will provide guidance to clinicians regarding appropriate use in specific indications, product selection, dosage and titration, and appropriate monitoring of both efficacy and safety,鈥� Dr Mersiades said.
Professor Iain McGregor, psychopharmacologist and Director of the Lambert Initiative for Cannabinoid Therapeutics at the University of Sydney, said聽聽had given medicinal cannabis a 鈥済old star鈥� for its efficacy in CINV.
However, he said, many of the 28 studies evaluated in the review were conducted more than 30 years ago, so more up-to-date clinical trials were needed.
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Medicinal cannabis and nausea: the wait for good evidence - .
