What is meningococcal disease?
As a medical researcher and parent of two teenagers there is one bug,听Neisseria meningitidis, that really scares me. This is mainly because of the speed and severity of the infection it causes, called听, and its predilection for infecting healthy adolescents and younger children.
Meningococcal is a rare but very serious infection that听听blood poisoning (septicaemia) and/or brain infection (meningitis).
The initial symptoms can be vague and non-specific. This includes the sudden onset of fever and a rash. The rash can be either red-purple spots or bruises 鈥� detected by the classic听听to see if the rash goes away (and is therefore less likely to be meningococcal) 鈥� or a flat or raised non-specific rash.
Other symptoms can be mistaken for disease like the flu and include headache, neck stiffness, reduced consciousness, muscle aches, joint pain, nausea and vomiting. If you are at all worried see your GP.
Once infected the听听is around 5鈥�10%. About 10鈥�30% of children and adolescents who survive the disease听, such as limb deformity, skin scarring, deafness and neurological deficits.
Early diagnosis and treatment with antibiotics can improve the patient鈥檚 outcomes but the disease can largely be prevented by vaccination.
How common is meningococcal disease?
Using differences in the surface 鈥渟ugars鈥� (polysaccharides) of the听Neisseria meningitidisorganism鈥檚 outer membrane capsule, we are able to classify the bacteria into serogroups (types), and each serogroup is given a letter of the alphabet, for example, A, B, C and so on. There are 13 different serogroups.
Globally, most meningococcal disease is caused by serogroups A, B, C, W and Y. These were chosen as the targets for vaccines.
The bug poses the greatest risk of infection in those people with immune system weaknesses. But healthy people in our community who are smokers, live in crowded living conditions, engage in intimate kissing with multiple partners (hence adolescents and young adults), and those with a recent or current viral respiratory infection are also targets.
The burden of meningococcal disease fluctuates naturally over time. The rate declined from 2002 to 2013, but has been on the increase since 2014.
Serogroup C disease has become very rare (听in 2016) since the introduction of a free vaccine in 2003.
Serogroup B disease听, but has been naturally declining in most states and territories, even without widespread vaccination against this serogroup.
Serogroup W disease has increased since 2013. This is now the main cause of meningococcal disease in Australia,听听in 2016.
Children aged under two years have the highest rates of meningococcal W and Y disease, followed by older adolescents.
Vaccination options
No single vaccine offers protection against all serogroups that cause meningococcal disease, but there are safe and effective vaccines that can protect against five serogroups (A,B,C,W,Y). The vaccines cover different serogroups and it does get confusing so here are the basics.
There are three types of meningococcal vaccines registered in Australia, which cover the following serogroups:
- Meningococcal C (MenC)
- Meningococcal B (MenB)
- Meningococcal A, C, W, Y (MenACWY).
All these vaccines include 鈥渒illed鈥� parts of the bacteria in order to stimulate an immune response. This means if someone comes into contact with the bacteria, for example via kissing, then they already have immunity and don鈥檛 get the nasty disease. It鈥檚 not possible for the vaccine to cause meningococcal disease.
Menigococcal C vaccine
The MenC vaccine is given for free to all Australian infants at 12 months of age under our听. It鈥檚 given as a combination vaccine with the trade name Menitorix庐 and protects against meningococcal C and another bacteria called听.
The MenC vaccine has reduced the rate of meningoccocal C听听since its introduction.
Although serogroup C disease is now not common, it鈥檚 not completely eradicated so get your child vaccinated at 12 months.
Menigococcal B vaccine
罢丑别听, which has the trade name Bexsero庐, is not on the national immunisation program and will cost you around A$95-150 per dose, depending on what your pharmacist or GP charges. It might be worth calling a few different pharmacies to check their price.
It鈥檚 strongly recommended for people who either have immune system weaknesses, work in environments where there鈥檚 a high chance of exposure (such as health care or laboratory workers), or live in close proximity to others (such as military recruits and those in boarding houses or residential accommodation).
Children, especially those aged under two, and adolescents aged 15 to 19 years are also at increased risk.
The younger you start the MenB vaccine the more doses you need. If starting between six weeks to five months old, the child needs three doses; if over six months old, then two doses. Adolescents only need one dose.
Infants should be given a medicine like paracetamol at the time of vaccination to reduce the chance of the vaccine causing a fever.
Menigococcal ACWY vaccine
听are available in Australia, which have the trade names of Menveo庐, Menactra庐 and Nimenrix庐.
Like the MenB vaccine, the number of doses needed depends on the age you start vaccinating (babies under six months need four doses; 7- to 11-month olds need two doses and 12-23 month olds need one or two doses (either one dose of Nimenrix庐 or two doses of Menveo庐); and if started over two years, the child only needs one dose). Menveo庐 is the only vaccine registered for use in babies under one.
In all states except South Australia (where a MenB program is currently underway), MenACWY will be given to adolescents in years 11 and 12 via high school-based programs. This is in response to the recent emergence of MenW disease around parts of the country.
Parents wanting to vaccinate younger children will have to pay around A$55-90 per dose, depending on the brand you choose and what your pharmacist and GP charges. (Again, different pharmacies may have different prices).
What should you get?
The inevitable question parents ask is, 鈥渟hould I pay to get my child vaccinated against MenB and MenACWY?鈥�
In an ideal world, the answer would be 鈥済ive both vaccines鈥�. If you or your child has immune system weaknesses then definitely听.
Another way to answer would be to state what we know. We know both vaccines are effective against severe disease. We know they can be given on the same day safely. But we also know no vaccine is 100% effective, and a person may still become infected even after immunisation.
If you are very worried your child may have meningococcal disease, whether vaccinated or not, seek medical advice immediately.
听
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