高清福利片

高清福利片_

The Simpson Prize 2025 | Highly Commended - Caitlin Andrews

23 October 2025
What if ageing was negotiable? A study that skipped the hype and found that real food might still be the best medicine鈥 and didn鈥檛 try to sell me anything
Dr Caitlin Andrews works across disciplines in the Charles Perkins Centre and the School of Life and Environmental Science, Faculty of Science at the University of Sydney. This essay was joint highly commended in the inaugural The Stephen J Simpson Prize for Research Translation 2025.

I鈥檝e always been partial to a good health metric. Resting heart rate? Love it. Sleep score? Addicted. I once tracked my blood glucose for a week just to see what happened after a cinnamon scroll. (Spoiler: my pancreas sent a cease-and-desist and ghosted me entirely.)

So, when I stumbled across a study claiming that a six-week dietary intervention could improve how fast your body is aging, I did what any health-curious journalist would do: I clicked, I read, and I spiralled.

The study, conducted by researchers at The University of Sydney鈥檚 Charles Perkins Centre, asked a deceptively simple question: Can what we eat 鈥 just for six weeks 鈥 change how old we are on the inside? Not in a 'reverse the clock', Benjamin Button kind of way. No creams. No cryotherapy. No powdered deer antler. Just food. Real food.


"As we age, our health tends to decline. It鈥檚 an inconvenient biological truth. This is where the idea of biological age comes in: it doesn鈥檛 just measure the passage of time but asks how well your body is holding up under its share of wear and tear."

Dr Caitlin Andrews


To measure this, they used something called the Klemera-Doubal Method (KDM). Sounds like a Cold War cipher, right? Actually, it鈥檚 an algorithm. Clever enough to take routine health markers like blood pressure, cholesterol, BMI, and blood cell counts, and crunch them into a single estimate of the age gap between your body and your birth certi铿乧ate (turns out maths isn鈥檛 totally useless). Wild. And this gap? It鈥檚 not just dinner party trivia. It鈥檚 your body鈥檚 risk assessment for future breakdowns: age-related potholes, functional slowdowns, or an early curtain call.

As we age, our health tends to decline (because apparently, life thought saggy knees and random groans would be hilarious). It鈥檚 an inconvenient biological truth that explains why standing up during your 'golden years' feels like a high-stakes operation鈥 complete with creaks, cracks, and a standing ovation if you manage it without wincing. This is where the idea of biological age comes in: it doesn鈥檛 just measure the passage of time but asks how well your body is holding up under its share of wear and tear.

Whether it's marching, jogging, or wheezing behind the parade.

If your body鈥檚 internal age is higher than your actual age, it鈥檚 like your organs are ageing ahead of schedule... pulling double shifts under bad management. Think milk left out in the sun. Not great. But if it鈥檚 lower, your insides are aging with the grace of a vintage wine: slow, steady, and... smug. And the bigger the gap in the right direction, the better. That's what the researchers were measuring. Whether diet could nudge that gap in the right direction.

Let鈥檚 be clear: This algorithm doesn鈥檛 tell you how old you are. That鈥檚 the job of your birth certi铿乧ate and the teen at the checkout who calls you 'ma鈥檃m'. Instead, it listens to your body鈥檚 internal chatter and asks, 'compared to others your age, are you thriving, surviving, or running on fumes?'. It鈥檚 not about decoding some mystical 'true age'. It鈥檚 about health. The status of your health, in the context of your age. Think of it this way: if chronological age is the number of years, you鈥檝e owned the car, the KDM algorithm gives us the mechanic鈥檚 report鈥攁ll the useful stuf about how well the engine鈥檚 running.

The study involved 104 older adults (65-75 years) randomly assigned to one of four tightly controlled diets:

  • omnivorous high-fat (OHF): rich in animal protein and fat, not far off the average Aussie plate: meat-heavy, low on legumes, and suspiciously beige - the culinary equivalent of shrugging at your arteries
  • omnivorous high-carb (OHC): still omnivorous, but with more whole grains and complex carbs, think meat-eater who鈥檚 discovered quinoa and isn鈥檛 mad about it
  • semi-vegetarian high-fat (VHF): mostly plant-based, with a generous helping of olive oil, nuts, and the occasional cheese cameo, the diet equivalent of a 铿俥xitarian who shops at the farmers鈥 market and says things like 鈥業 don鈥檛 eat meat, except when I do鈥
  • semi-vegetarian high-carb (VHC): the most plant-based and 铿乥re-rich of the bunch, think lentils, legumes, whole grains, and vegetables -basically, if a diet could wear Birkenstocks and compost, it would be this one.

All meals were provided. All health markers were measured. No one was asked to juice celery or chant affirmations to their mitochondria.

The results? The OHF group 鈥 whose diet most closely resembled the average Australian diet 鈥 showed no signi铿乧ant change in the age gap between body and birth certi铿乧ate.

But the other three groups, especially those eating more 铿乥re and fewer processed fats, showed improvements. Their bodies started aging more slowly than expected. Not dramatically. But measurably. In just six weeks.

As someone who鈥檚 spent years watching the wellness industry sell youth in increasingly absurd packaging 鈥 collagen water, mushroom coffee, 鈥渁nti-ageing鈥 toothpaste 鈥 this study felt refreshingly... boring. No superfoods. No supplements. Just more legumes, fewer saturated fats, and a bit of dietary humility.

Of course, the researchers were careful not to overstate their 铿乶dings. This wasn鈥檛 a prescription. It wasn鈥檛 a promise. It was a signal 鈥 a suggestion that our internal systems might be more responsive to diet than we thought, even in later life.

I called one of the researchers to ask what this all meant. 鈥淲e鈥檙e not saying you can reverse aging. But we are saying that biological age is dynamic. It鈥檚 not 铿亁ed. And that opens up some interesting possibilities.鈥

Interesting indeed. Because if biological age is a moving target, then health isn鈥檛 just about avoiding disease. It鈥檚 about maintaining system integrity. It鈥檚 about how well your body adapts. Recovers. Communicates with itself. Something a single biomarker can鈥檛 tell you.

The study didn鈥檛 test a product. It tested a pattern. A way of eating that emphasized whole foods, complex carbohydrates, and plant-based proteins. The kind of diet that鈥檚 been quietly recommended by public health guidelines for decades. In just six weeks, participants on higher-铿乥re, lower-fat diets showed a meaningful shift (think, dysfunctional family dinner to civil office meeting 鈥 still some occasional side-eyes, but everyone鈥檚 mostly playing nice).

That鈥檚 the kind of result that doesn鈥檛 just make headlines. It makes policy advisors sit up straighter in their ergonomic chairs. Because if a short-term dietary intervention can measurably improve the age gap between your body and your birth certi铿乧ate, what does that mean for aged care nutrition? For chronic disease prevention? For how we talk about healthy aging 鈥 not as a luxury, but as a system-level investment?

The implications are quietly radical. This wasn鈥檛 a longevity pill. It was lentils. It was 铿乥re. It was minimally processed, whole foods. The kind of stuf that doesn鈥檛 promise to 鈥渄etox your aura鈥. It was a reminder that the most powerful interventions often look suspiciously like common sense (the one thing that never trends, never sells, and never gets invited to wellness expos). The kind of advice that鈥檚 been around since before kale had a PR team.

Even after a lifetime of nutritional misdemeanours鈥 Kellogg's fun packs. Drive-thru dinners. Sodium-fuelled nostalgia. Your body might still be open to negotiation. Turns out, your cells aren鈥檛 holding a grudge about the 鈥90s. Or the 2000s. Or last Tuesday. Change is possible. Not guaranteed. But possible.

And that possibility matters. Especially in a world where aging is often framed as a decline, a loss, a slow fade to grey. What if we reframed it as adaptation? As resilience? As a system that, with the right inputs, can still surprise us?

As I wrapped up my interview, I asked the researcher what they hoped people would take away from the study. 鈥淭hat health is a system,鈥 they said. 鈥淎nd systems respond to care.鈥

I liked that. It felt human. It felt hopeful. And it felt like progress. So no, I didn鈥檛 rush to upload my bloodwork to a website claiming to reveal if I鈥檓 aging like a vintage shiraz or a banana left on a dashboard. At the ripe young age of 49, I don't need tests and wearables to con铿乺m whether I鈥檓 biologically 25 or just really good at denial (obviously not the latter). This research wasn鈥檛 about turning biomarkers into a horoscope.

It wasn't to offer a tool for self-diagnostics or personalized prophecy. The researchers used biological age as a research tool, not a party trick. they were showing how diet 鈥 not ego or fads 鈥 can shift the odds. Shift your risk of age-related disease, early functional decline, or an early exit, all relative to the number on your birth certi铿乧ate.

But I did go and buy some lentils. And now I've started thinking less about the number of candles on the cake and more about whether I can blow them out without needing a nap after. Which, for a chronically curious health nerd who still can鈥檛 铿乶d their reading glasses without a full archaeological dig, feels like progress.

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